Src Kinase Inhibitors as Anticancer Agents
Kim Arndt, director in oncology at Wyeth Research, discusses compounds his company analyzed for their ability to inhibit tumor growth in mice.
View ArticleChemical Biology
How the tools of an emerging interdisciplinary field are helping scientists to explain cell activity and develop new drugs.
View ArticleBetter Living through Chemistry
Novel small molecules, temporally activated proteins, and highly engineered peptides are offering new methods for understanding cell biology.
View ArticleGreening the Built Environment
New materials like glass concrete and electrochromic windows can save energy and valuable resources.
View ArticleThe Shape of Things
Scientists are creating nonnatural receptors, nucleic acid analogs, and small molecules to bypass natural defense mechanisms that hinder treatment of diseases or infections.
View ArticleCells and Sulfur
Research in sulfur biochemistry will increase our ability to fight pathogens, produce vitamins, and understand basic metabolism.
View ArticleScience In Silico
At one time scientists' most valuable tools were microscopes and telescopes. Today, in fields as diverse as systems biology, protein modeling, and weather prediction, it may well be the computer.
View ArticleStructural Creativity
Non-natural β-peptides, peptide nucleic acids, and peptoids can serve as probes, scaffolds, and building blocks for protein-like structures.
View ArticleGreen Chemistry
A growing awareness of the disadvantages of current industrial practices has resulted in the development of safe and efficient technologies that use renewable resources.
View ArticleDesigner Generation
Computational design and other techniques illustrate the variety of ways to use chemistry to solve biological problems.
View ArticleHow to Build a Better Protein
Natural protein design has been refined over billions of years of evolution, but scientists are now taking on this task using principles gleaned from mere decades of study.
View ArticleIncredible Anaerobes: From Physiology to Genomics to Fuels
The volume presents current work on the physiology and unique features of anaerobes.Full table of contents
View ArticleThe Maillard Reaction: Recent Advances in Food and Biomedical Sciences
This volume addresses a wide range of interdisciplinary research reports on the role of Maillard reactions in aging and disease.Full table of contents
View ArticleBiocatalysts and Biosurfactants
Microbial products can take the place of toxic chemicals in some chemical syntheses, reducing undesirable impacts on the environment and human health.
View ArticleTurn Down the Volume
Mini-laboratories for studying protein crystallization and viscous polymer behavior reveal the power and beauty of small scale approaches.
View ArticleSteroid Enzymes and Cancer
An exploration of the consequences of abnormal synthesis of steroid hormones in individual target tissues, a process that has assumed an increasing importance in our understanding of malignancies.
View ArticleCharge and Release
Researchers are developing "intelligent" materials that respond to changes in their environment in ways that solve engineering challenges. Products like "smart" food packaging have even begun entering...
View ArticlePotent Pathways
Protein kinases play a key role in almost every major pathway in eukaryotic cells. Structural approaches, including a new method called fragment-based drug design, are identifying potential targets...
View ArticleTrends in Chemical Biology 2009
Graduate students and postdocs from chemical biology labs around the New York area describe efforts to find and synthesize molecules that bind to proteins or DNA in useful ways.
View ArticleSomething Borrowed, Something New
From traditional Asian herbs to high-tech computational approaches, chemical biologists are using everything in their arsenal to identify promising new drug candidates.
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