Src Kinase Inhibitors as Anticancer Agents
Kim Arndt, director in oncology at Wyeth Research, discusses compounds his company analyzed for their ability to inhibit tumor growth in mice.
View ArticleChemical Biology
How the tools of an emerging interdisciplinary field are helping scientists to explain cell activity and develop new drugs.
View ArticleBetter Living through Chemistry
Novel small molecules, temporally activated proteins, and highly engineered peptides are offering new methods for understanding cell biology.
View ArticleGreening the Built Environment
New materials like glass concrete and electrochromic windows can save energy and valuable resources.
View ArticleThe Shape of Things
Scientists are creating nonnatural receptors, nucleic acid analogs, and small molecules to bypass natural defense mechanisms that hinder treatment of diseases or infections.
View ArticleCells and Sulfur
Research in sulfur biochemistry will increase our ability to fight pathogens, produce vitamins, and understand basic metabolism.
View ArticleScience In Silico
At one time scientists' most valuable tools were microscopes and telescopes. Today, in fields as diverse as systems biology, protein modeling, and weather prediction, it may well be the computer.
View ArticleStructural Creativity
Non-natural β-peptides, peptide nucleic acids, and peptoids can serve as probes, scaffolds, and building blocks for protein-like structures.
View ArticleGreen Chemistry
A growing awareness of the disadvantages of current industrial practices has resulted in the development of safe and efficient technologies that use renewable resources.
View ArticleDesigner Generation
Computational design and other techniques illustrate the variety of ways to use chemistry to solve biological problems.
View ArticleHow to Build a Better Protein
Natural protein design has been refined over billions of years of evolution, but scientists are now taking on this task using principles gleaned from mere decades of study.
View ArticleIncredible Anaerobes: From Physiology to Genomics to Fuels
The volume presents current work on the physiology and unique features of anaerobes.Full table of contents
View ArticleThe Maillard Reaction: Recent Advances in Food and Biomedical Sciences
This volume addresses a wide range of interdisciplinary research reports on the role of Maillard reactions in aging and disease.Full table of contents
View ArticleBiocatalysts and Biosurfactants
Microbial products can take the place of toxic chemicals in some chemical syntheses, reducing undesirable impacts on the environment and human health.
View ArticleTurn Down the Volume
Mini-laboratories for studying protein crystallization and viscous polymer behavior reveal the power and beauty of small scale approaches.
View ArticleSteroid Enzymes and Cancer
An exploration of the consequences of abnormal synthesis of steroid hormones in individual target tissues, a process that has assumed an increasing importance in our understanding of malignancies.
View ArticleCharge and Release
Researchers are developing "intelligent" materials that respond to changes in their environment in ways that solve engineering challenges. Products like "smart" food packaging have even begun entering...
View ArticlePotent Pathways
Protein kinases play a key role in almost every major pathway in eukaryotic cells. Structural approaches, including a new method called fragment-based drug design, are identifying potential targets...
View ArticleTrends in Chemical Biology 2009
Graduate students and postdocs from chemical biology labs around the New York area describe efforts to find and synthesize molecules that bind to proteins or DNA in useful ways.
View ArticleSomething Borrowed, Something New
From traditional Asian herbs to high-tech computational approaches, chemical biologists are using everything in their arsenal to identify promising new drug candidates.
View ArticleSolar's Softer Side
Because of the lower cost of materials, flexible solar technology has the potential to be competitive with non-renewable sources of electricity such as coal or natural gas. Scientists discussed...
View ArticleGlobal Metabolite Profiling
This eBriefing focuses on emerging strategies for global metabolite profiling and how these technologies are being applied to the field of "functional genomics"—the ultimate goal being discovery of the...
View ArticleToward an in silico Cell
Accurately modeling molecular behavior of cells remains a Holy Grail of the biomodeling community. In this eBriefing, hear leading experts in computational and experimental analysis of large biosystems...
View ArticleFrom Crumpling Geometries to Graphene Materials
This eBriefing includes presentations from faculty, postdocs, and students in the New York City—brought together to share their ideas and research on condensed matter physics.
View ArticleFrom Strained Suspensions to Magnetoelectronic Materials
This eBriefing includes presentations from faculty, postdocs, and students in the New York City—brought together to share their ideas and research on condensed matter physics.
View ArticleEnvironmental Research
This eBriefing highlights environmental research presented at the Qatar Foundation Annual Research Forum. Topics include soil science, advances in chemical processes and products, CO2 management, and...
View ArticleEnergy Research
This eBriefing highlights energy research presented at the Qatar Foundation Annual Research Forum. Topics include fossil fuel and renewable energy research, and energy efficiency in buildings.
View ArticleChemical Biology of Infectious Diseases
This eBriefing covers infectious disease at a molecular level, including bacterial "group behavior" called quorum sensing, bacterial signal transduction pathways, and the development of new...
View ArticleChemical Engineering Approaches to Challenges in Energy and Biomedicine
The field of chemical engineering—poised at the interface of chemistry, engineering, and biomedicine—is well positioned to solve global challenges. This eBriefing reviews the role of chemical...
View ArticleFrom Colloidal Systems to Frustrated Magnets
At the seventh biannual Gotham-Metro Condensed Matter conference faculty, postdocs, and students shared ideas and research on condensed matter with fellow physicists, covering the spectrum from...
View ArticleBlack Holes and Astrobiology
This eBriefing documents a presentation by Caleb Scharf, director of astrobiology at Columbia University, who described the latest science on black holes and gave an update on the search for life on...
View ArticleThe 8th Gotham-Metro Condensed Matter Meeting
This eBriefing documents the 8th condensed matter physics conference featuring keynote talks in hard matter and soft matter as well as a special panel discussion, "Generation Tech: Tapping NYC's...
View ArticleNanomedicines
This eBriefing explores regulatory challenges in the nascent field of nanomedicines, focusing on the relevance and adequacy of existing frameworks, the availability and expertise of regulators, and...
View ArticleSystems Biology Approaches to Secondary Metabolites and Metabonomics
Secondary metabolites, or idiolites, play many roles in biological systems, including communication, defense, and signaling. This eBriefing explores a systems biology approach to secondary metabolites...
View ArticleClick Chemistry in Biology and Medicine
Click chemistry mimics the simplicity of reactions found in nature for synthesizing large complex molecules, proceeding via the stepwise addition of small building blocks with minimal toxic byproducts....
View ArticleSpecial Issue: Countermeasures Against Chemical Threats I
Chemical threats, both accidental and deliberate, are of critical concern globally. This, the first of two Annals issues devoted to this topic, presents 23 papers that discuss various countermeasures...
View ArticleSpecial Issue: Countermeasures Against Chemical Threats II
Chemical threats, both accidental and deliberate, are of critical concern globally. This issue, the second of two devoted to this topic, presents 19 papers that discuss various countermeasures against...
View ArticleMicroRNAs
MicroRNAs (miRNA) play critical roles in regulating gene expression. This symposium will present up-to-date basic, translational, and clinical research addressing the biology of miRNA and their promise...
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